The product is indicated as: External antiparasitic for the treatment and control of fleas, ticks and biting lice in dogs and cats.
FRONTLINE Â® PLUS quickly control new infestations of adult fleas ( Ctenocephalides felis and Ctenocephalides canis ) for up to 3 months depending on the degree of infestation of fleas in the environment.
FRONTLINE Â® PLUS prevents the development of eggs, larvae and pupae deposited by adult fleas acquired up to two months after application.
FRONTLINE Â® PLUS dogs quickly controls up to four weeks and at all stages reinfestations tick Rhipicephalus sanguineus , FRONTLINE Â® PLUS rapidly removes chewing lice infestations caused genre by Trichodectes in dogs (adults and puppies).
FRONTLINE Â® PLUS cat quickly controls reinfestation by adult fleas, protecting the animal, for up to five weeks after application.
FRONTLINEÂ® PLUS prevents the development of eggs and larvae deposited by adult fleas acquired up to 5 weeks after application FRONTLINEÂ® PLUS rapidly removes chewing lice infestations caused genre by Felicola in cats.
For the treatment and control of flea allergy dermatitis (DAP) it is recommended to apply monthly in allergic animals and dogs and cats cohabit with them.
ADMINISTRATION AND DOSAGE
Management Mode : Select the correct presentation for the weight of the animal to be treated: Remove the pipette from the packaging. Cut the pipette at the level of the upper part marked, empty the entire contents of it directly on the skin, in a patch of about 4-5 cm, separating the hair of the animal between the shoulder blades to prevent licking, as this could cause a sub-dosage of the product. Try not to soak the hair, which could give a sticky aspect the focus of treatment. If that happens, the effect will disappear within 24 hours of the application.
The ability of diffusion of molecules of fipronil and (S) -methoprene can apply FRONTLINE Â® PLUS at one point and ensure proper distribution of the product throughout the animal 's body.
FRONTLINE Â® PLUS can be used in puppies from 8 weeks of age. The product takes 24 hours spread over the animal 's hair. It is not recommended to bathe the animal during the 48 hours before and after treatment with FRONTLINE Â® PLUS.
Ticks die during the first 24-48 hours after accession.
Cats: The minimum recommended dose is 5 mg of fipronil and 6 mg of (S) -methoprene per kg of bodyweight, in dermal application or a 5 ml pipette for a cat.
Dogs: The minimum recommended dose is 6.7 mg of fipronil and 6 mg of (S) -methoprene per kg body weight, in topical application.
In the absence of data on safety, the minimum treatment interval is 4 weeks.
ROUTE OF ADMINISTRATION : External use, cutaneous application.
CONTRAINDICATIONS: In the absence of available data, the product should not be used in puppies less than 8 weeks old and / or puppies weighing less than 2 kg or kittens weighing less than 2 kg or kittens weighing less than 1 kg.
Do not use in sick or convalescent animals (systemic diseases, fever ...).
Do not use in rabbits, as adverse reactions may occur even resulting in death.
Do not use in cats presentations intended for the dog, as this may lead to overdosing.
Adverse effects (frequency and seriousness) If licking, it can be observed a brief period of hypersalivation mainly due to the nature of the excipient.
Sporadically been reported the following adverse reactions after using the product:
- Transient skin reactions at the application site (skin discoloration, Local alopecia, pruritus, erythema) and generally pruritus or alopecia.
Exceptionally, after the drug has been observed:
reversible neurological-symptoms (hyperesthesia, depression, nervous symptoms)
-VÃ³mito Or respiratory symptoms.
Special precautions for use: It is important to ensure that the product is applied in an area where the animal can not suck and animals not suck each other after treatment.
Apply the product as indicated in the product insert.
Keep out of reach of children.
In the dog: bathing / immersion in water should be avoided for 2 days after application of the product as well as bathrooms more frequent than once a week, since no studies have been conducted to investigate how it affects the efficacy of the product.
Before treatment, shampoos emollients can be used, but reduce the duration of protection from fleas to approximately 5 weeks when used weekly after product application. A weekly bath with a medicated shampoo 2% chlorhexidine did not affect efficacy against fleas during a 6 week period.
It should not allow dogs to swim in streams or ponds during the 2 days after application.
There may be an attachment of single ticks. For this reason it can not completely exclude the transmission of infectious diseases if conditions are unfavorable.
Fleas animals usually infest the basket, bedding and resting areas of these, such as carpets and certain types of furniture that should be treated in case of massive infestation with a suitable insecticide, at the beginning of the control measures and cleaned regularly with a vacuum cleaner.
In cats: data to evaluate the effect of a bath or shampoo in the efficacy of the product in cats are not available. However based on information available dogs shampoo for 2 days after application, it is not advisable to bathe the animals in the two days after applying the product.
Avoid contact with eyes and mouth.
Animals or users known to insecticides or alcohol hypersensitivity should avoid contact with FRONTLINE Â® PLUS.
Avoid contact of the product with your fingers. If this occurs, wash hands with soap and water.
After accidental eye exposure, wash the eye gently with pure water.
Wash hands after use.
Treated animals should not be touched until the point of application of the product is dry and should not allow children to play with treated animals until the application site was dry. Therefore it is recommended not to treat animals during the day, if not in the evening, and that recently treated animals are not allowed to sleep with owners, especially children.
Do not smoke, eat or drink during application.
Use during pregnancy or lactation : FRONTLINE Â® PLUS can be used during pregnancy and lactation in cats or dogs.
overdose : The risk of experiencing adverse effects may increase in cases of overdose.
In cats: No adverse effects were observed in the tolerance studies in cats and kittens 8 weeks or older and weighing about 1 kg treated every month for 6 months to 5 times the recommended dose. It was observed that after treatment itching may occur. An overdose of product may cause a sticky appearance of hair at the site of application. However, in these cases, these signs disappear 24 hours after application.
In the dog: You have no demonstrated adverse effects in studies of tolerance in puppies 8 weeks and dogs about 2 kg treated with 5 times the recommended dose.
Special precautions for the environment or waste disposal: Fipronil and (S) -methoprene may adversely affect aquatic organisms.
Do not discard the product or empty containers in ponds, rivers or streams.
Empty packaging and any remaining product should be disposed wrapping paper packaging and place it in the trash.
Pharmacodynamic properties Fipronil is an insecticide and acaricide belonging to the phenylpyrazole family. It acts through interaction with complexes formed between the chloride channels and their ligands, especially the neurotransmitter GABA (gamma-aminobutyric acid), thus blocking the transfer of chloride ions through the cell membrane and postsynaptic pre levels. Therefore, it makes uncontrolled activity of the central nervous system in insects and mites lead to death. Fipronil kills fleas within 24 hours, ticks (Dermacentorvariabilis, Rhipicephalus sanguineus, Ixodesscapularis, Ixodes ricinus, Haemaphysalys longicornis, Haemaphysalis yellow, Haemaphysalis campanulata) and lice within 48 hours after product application.
The (S) -methoprene is a growth regulator of insects (IGR) of the class of juvenile hormone, which inhibits the development of immature stages of insects. mimicking the action of the hormone, the compound causes developmental problems and death of immature stages.
The ovicidal activity of (S) -methoprene applied to the results of animals is by direct membrane penetration of eggs or newly laid or by absorption through the cuticle of adult flea fleas. The (S) -methoprene is also effective to prevent the development of larvae, prevents contamination of the habitat of the animals treated with flea immature stages.
Pharmacokinetics Metabolism studies have shown that Fipronil is mainly transformed into fipronil sulfone derivative. The (S) -methoprene is highly degraded to carbon and which is incorporated acetate endogenous substances dioxide. Pharmacokinetics after topical administration of fipronil and (S) -methoprene in association it has been studied in cats compared to each active ingredient. This allowed us to estimate the absorption and other pharmacokinetic parameters under the conditions of use. In cats after administration of the association topically with a potential oral exposure from licking; Fipronil has the absolute bioavailability (18%) with a mean maximum plasma concentration of about 100 ng / ml for fipronil and 13 ng / ml for firponil sulfone. For after administration of the association topically dogs, Fipronil is very little (11%) absorbed with an average maximum plasma concentration of approximately 35 ng / ml fipronil and 55 ng / ml for the sulfone fipronil. For cats fipronil plasma levels quickly they reached a peak average about 6 hours and decreases with a half life of about 35 hours. For dogs, Fipronil peaked in plasma concentrations slowly, the average was about 101 hours and slowly decreasing (half life of about 154 hours, the highest values were observed in males). Fipronil is slightly metabolised to fipronil sulfone in cats. Plasma concentrations of S (S) -methoprene are generally below quantitation (20 ng / ml) in cats and dogs after topical administration. Fipronil and its major metabolite and (S) -methoprene spread widely in the dermis cat a day after application. Concentrations of fipronil, fipronil sulfone and (S) -methoprene decreased over time, but are detectable at least 59 days after application in cats and 60 days after application in dogs. Parasites are killed mainly by contact rather than by systemic exposure. No pharmacological interference between fipronil and (S) -methoprene detected.
STORAGE: Store in a cool place in the original packaging.
Keep in a place protected from sunlight.
Do not store above 30 0 C.
*Make sure to consult your Veterinarian before buying any medication.
Reviews Frontline Plus Large - fipronil & methoprene
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